scholarly journals Medullary carcinoma of breast: An immunohistochemical study of its lymphoid stroma

Cancer ◽  
1981 ◽  
Vol 48 (6) ◽  
pp. 1368-1376 ◽  
Author(s):  
Su-Ming Hsu ◽  
Laurence Raine ◽  
R. N. Nayak
Keyword(s):  
Immunohistochemical Study ◽  
Medullary Carcinoma ◽  
Lymphoid Stroma

Synchronous medullary carcinoma of thyroid and ductal carcinoma of breast: A report of a rare case with immunohistochemical study

2016 ◽  
Vol 13 (1) ◽  
pp. 27
Author(s):  
RupaliR Bavikar ◽  
SanjayD Deshmukh ◽  
Hemant Lekawale ◽  
Lalit Datar ◽  
Bageshri Gogate ◽  
...  
Keyword(s):  
Rare Case ◽  
Ductal Carcinoma ◽  
Immunohistochemical Study ◽  
Medullary Carcinoma

scholarly journals Clinicopathological Features and Prognostic Implication of Gastric Carcinoma with Lymphoid Stroma

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jung-Soo Pyo ◽  
Nae Yu Kim ◽  
Byoung Kwan Son ◽  
Hyo Young Lee ◽  
Il Hwan Oh ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Meta Analysis ◽  
Survival Rates ◽  
Medullary Carcinoma ◽  
Tumor Location ◽  
Lymphatic Invasion ◽  
Clinicopathologic Characteristics ◽  
Lymphoid Stroma ◽  
Significant Difference ◽  
Prognostic Implications

Background/Objective. Gastric carcinoma with lymphoid stroma (GCLS) has been referred to as lymphoepithelioma-like carcinoma and medullary carcinoma. The present study aims at elucidating the clinicopathologic features and prognostic implications of GCLS through a meta-analysis. Methods. This study included 34 eligible studies and 1757 GCLSs. The clinicopathologic characteristics of GCLS were investigated from eligible studies, and the meta-analysis was performed. In addition, we compared the survival rates between GCLS and non-GCLS. Results. The estimated rate of GCLS was 0.062 (95% confidence interval (CI) 0.040-0.097). GCLS was significantly correlated with the diffuse type of Lauren’s classification, proximal tumor location, less-frequent lymphatic invasion, and lower pTNM stage. However, there was no significant difference in age, sex, tumor differentiation, vascular invasion, perineural invasion, pT stage, lymph node metastasis, and distant metastasis between GCLS and non-GCLS patients. EBV positive rates in GCLS and non-GCLS patients were 0.723 (95% CI 0.643-0.791) and 0.064 (95% CI 0.039-0.103), respectively. HER2 expression in GCLS was significantly lower than that in non-GCLS. GCLS patients had a more favorable prognosis than that of non-GCLS patients (hazard ratio 0.500, 95% CI 0.305-0.821). Conclusion. GCLS comprised 6.2% of overall GC and more frequent in the proximal portion of the stomach. Since GCLS was associated with better prognosis, the histologic finding can be useful for predicting the patient’s prognosis.

scholarly journals A case of poorly differentiated adenocarcinoma with lymphoid stroma originated in the ascending colon diagnosed as lymphoepithelioma-like carcinoma

2019 ◽  
Vol 13 (4) ◽  
pp. 538-544
Author(s):  
Kengo Kai ◽  
Hideki Hidaka ◽  
Takeshi Nakamura ◽  
Yuji Ueda ◽  
Kosuke Marutsuka ◽  
...  
Keyword(s):  
Large Intestine ◽  
Elective Surgery ◽  
Histopathological Examination ◽  
Case Reports ◽  
Medullary Carcinoma ◽  
Hepatic Flexure ◽  
Wall Thickening ◽  
Ascending Colon ◽  
Lymphoid Stroma ◽  
Poorly Differentiated

AbstractAn 86-year-old woman’s stool sample was positive for blood. Computed tomography (CT) showed wall thickening of the ascending colon at the hepatic flexure. Colonoscopy showed near-complete obturation by colon cancer. Since she was asymptomatic, elective surgery was planned. Laparoscopic right hemicolectomy was performed. Histopathological examination showed poorly differentiated carcinoma cells proliferating in a solid pattern with marked lymphocyte infiltration. The diagnosis was lymphoepithelioma-like carcinoma (LELC) associated with Epstein-Barr virus (EBV) infection; however, EBV-encoded small RNA–in situ hybridization was negative. Microsatellite instability was not assessed. The postoperative course was uneventful and she was discharged on the 15th postoperative day. She remains recurrence-free at 2 years after surgery. Past reports note that colorectal carcinomas with dense lymphoid stroma may be related to LELC or medullary carcinoma (MC). Gastrointestinal LELC is rare, with some reports on LELC of the esophagus and stomach. Reports on LELC of the large intestine are very rare. MC of the large intestine is relatively new concept, firstly described in the WHO Classification of Tumours of the Digestive System 3rd Edition in 2000. We herein present a case of lymphoepithelioma-like carcinoma of the ascending colon and relevant case reports about LELC and MC of the large intestine.

Warthin's tumor: An immunohistochemical study of its lymphoid stroma

1981 ◽  
Vol 12 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Su-Ming Hsu ◽  
Pei-Ling Hsu ◽  
Ramakrishna N. Nayak
Keyword(s):  
Immunohistochemical Study ◽  
Warthin’S Tumor ◽  
Lymphoid Stroma ◽  
Warthin's Tumor

Micronodular thymoma with lymphoid stroma: an immunohistochemical study of the distribution of Langerhans cells and mature dendritic cells in six patients

2014 ◽  
Vol 66 (2) ◽  
pp. 300-307 ◽  
Author(s):  
Yoshinori Ishikawa ◽  
Hisashi Tateyama ◽  
Megumi Yoshida ◽  
Koji Takami ◽  
Haruhisa Matsuguma ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Immunohistochemical Study ◽  
Lymphoid Stroma

scholarly journals A Case of Medullary Carcinoma with Lymphoid Stroma of the Stomach Showing 2 Tumors Which were Connected with Intraepithelial Spread

2004 ◽  
Vol 37 (12) ◽  
pp. 1823-1828
Author(s):  
Motoo Shinohara ◽  
Munetaka Mori ◽  
Akihiro Mimuro ◽  
Michiaki Yagyu ◽  
Nobuaki Sakamoto ◽  
...  
Keyword(s):  
Medullary Carcinoma ◽  
Lymphoid Stroma ◽  
Intraepithelial Spread

scholarly journals Comparative clinicopathological and immunohistochemical study of micronodular thymoma and micronodular thymic carcinoma with lymphoid stroma

2021 ◽  
pp. jclinpath-2021-207819
Author(s):  
Ping Ping Liu ◽  
Yun Chao Su ◽  
Yun Niu ◽  
Yan Fen Shi ◽  
Jie Luo ◽  
...  
Keyword(s):  
Mitotic Activity ◽  
Tumour Cell ◽  
Growth Pattern ◽  
Thymic Carcinoma ◽  
Immunohistochemical Study ◽  
Cell Component ◽  
Lymphoid Stroma ◽  
Cystic Changes ◽  
Epithelial Tumour ◽  
Thymic Carcinomas

AimTo elucidate the clinicopathological and immunohistochemical characteristics of micronodular thymomas (MNTs) and micronodular thymic carcinomas (MNCs) with lymphoid stroma.MethodsWe examined four cases of MNTs and three cases of MNCs pathologically and immunohistochemically.ResultsThere were prominent cystic changes infive of the seven cases. The neoplasms contained epithelial tumour cells arranged in a micronodular growth pattern lined by cystic walls and separated by abundant lymphoid stroma. Only the tumour cell component of MNCs showed signs of malignancy characterised by cytological atypia and increased mitotic activity. Neoplastic MNC epithelial cells showed strong positivity for CD5 and CD117. However, no immature lymphocytes (TdT-positive and CD99-positive) were present in and around the tumour nodules. None of the patients died or suffered from disease due to MNTs or MNCs.ConclusionMNTs and MNCs are rare and less aggressive forms of thymic tumours and can be differentially diagnosed by immunohistochemistry.

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